Endometrial organoids: a rising star for research on endometrial development and associated diseases
Y Song, AT Fazleabas - Reproductive Sciences, 2021 - Springer
Y Song, AT Fazleabas
Reproductive Sciences, 2021•SpringerThe endometrium is one of the most dynamic organs in the human body. Until now, cell lines
have furthered the understanding of endometrial biology and associated diseases, but they
failed to recapitulate the key physiological aspects of the endometrium, especially as it
relates to its complex architecture and functions. Organoid culture systems have become an
alternative approach to reproduce biological functions of tissues in vitro. Endometrial
organoids have now been established from stem/progenitor cells and/or differentiated cells …
have furthered the understanding of endometrial biology and associated diseases, but they
failed to recapitulate the key physiological aspects of the endometrium, especially as it
relates to its complex architecture and functions. Organoid culture systems have become an
alternative approach to reproduce biological functions of tissues in vitro. Endometrial
organoids have now been established from stem/progenitor cells and/or differentiated cells …
Abstract
The endometrium is one of the most dynamic organs in the human body. Until now, cell lines have furthered the understanding of endometrial biology and associated diseases, but they failed to recapitulate the key physiological aspects of the endometrium, especially as it relates to its complex architecture and functions. Organoid culture systems have become an alternative approach to reproduce biological functions of tissues in vitro. Endometrial organoids have now been established from stem/progenitor cells and/or differentiated cells by several methods, which represents a promising tool to gain a deeper understanding of this dynamic organ. In this review, we will discuss the establishment, characteristics, applications, and potential challenges and directions of endometrial organoids.
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